WHO: Slight cancer risk after Japan nuke accident


LONDON (AP) — Two years after Japan's nuclear plant disaster, an international team of experts said Thursday that residents of areas hit by the highest doses of radiation face an increased cancer risk so small it probably won't be detectable.


In fact, experts calculated that increase at about 1 extra percentage point added to a Japanese infant's lifetime cancer risk.


"The additional risk is quite small and will probably be hidden by the noise of other (cancer) risks like people's lifestyle choices and statistical fluctuations," said Richard Wakeford of the University of Manchester, one of the authors of the report. "It's more important not to start smoking than having been in Fukushima."


The report was issued by the World Health Organization, which asked scientists to study the health effects of the disaster in Fukushima, a rural farming region.


On March 11, 2011, an earthquake and tsunami knocked out the Fukushima plant's power and cooling systems, causing meltdowns in three reactors and spewing radiation into the surrounding air, soil and water. The most exposed populations were directly under the plumes of radiation in the most affected communities in Fukushima, which is about 150 miles (240 kilometers) north of Tokyo.


In the report, the highest increases in risk are for people exposed as babies to radiation in the most heavily affected areas. Normally in Japan, the lifetime risk of developing cancer of an organ is about 41 percent for men and 29 percent for women. The new report said that for infants in the most heavily exposed areas, the radiation from Fukushima would add about 1 percentage point to those numbers.


Experts had been particularly worried about a spike in thyroid cancer, since radioactive iodine released in nuclear accidents is absorbed by the thyroid, especially in children. After the Chernobyl disaster, about 6,000 children exposed to radiation later developed thyroid cancer because many drank contaminated milk after the accident.


In Japan, dairy radiation levels were closely monitored, but children are not big milk drinkers there.


The WHO report estimated that women exposed as infants to the most radiation after the Fukushima accident would have a 70 percent higher chance of getting thyroid cancer in their lifetimes. But thyroid cancer is extremely rare and one of the most treatable cancers when caught early. A woman's normal lifetime risk of developing it is about 0.75 percent. That number would rise by 0.5 under the calculated increase for women who got the highest radiation doses as infants.


Wakeford said the increase may be so small it will probably not be observable.


For people beyond the most directly affected areas of Fukushima, Wakeford said the projected cancer risk from the radiation dropped dramatically. "The risks to everyone else were just infinitesimal."


David Brenner of Columbia University in New York, an expert on radiation-induced cancers, said that although the risk to individuals is tiny outside the most contaminated areas, some cancers might still result, at least in theory. But they'd be too rare to be detectable in overall cancer rates, he said.


Brenner said the numerical risk estimates in the WHO report were not surprising. He also said they should be considered imprecise because of the difficulty in determining risk from low doses of radiation. He was not connected with the WHO report.


Some experts said it was surprising that any increase in cancer was even predicted.


"On the basis of the radiation doses people have received, there is no reason to think there would be an increase in cancer in the next 50 years," said Wade Allison, an emeritus professor of physics at Oxford University, who also had no role in developing the new report. "The very small increase in cancers means that it's even less than the risk of crossing the road," he said.


WHO acknowledged in its report that it relied on some assumptions that may have resulted in an overestimate of the radiation dose in the general population.


Gerry Thomas, a professor of molecular pathology at Imperial College London, accused the United Nations health agency of hyping the cancer risk.


"It's understandable that WHO wants to err on the side of caution, but telling the Japanese about a barely significant personal risk may not be helpful," she said.


Thomas said the WHO report used inflated estimates of radiation doses and didn't properly take into account Japan's quick evacuation of people from Fukushima.


"This will fuel fears in Japan that could be more dangerous than the physical effects of radiation," she said, noting that people living under stress have higher rates of heart problems, suicide and mental illness.


In Japan, Norio Kanno, the chief of Iitate village, in one of the regions hardest hit by the disaster, harshly criticized the WHO report on Japanese public television channel NHK, describing it as "totally hypothetical."


Many people who remain in Fukushima still fear long-term health risks from the radiation, and some refuse to let their children play outside or eat locally grown food.


Some restrictions have been lifted on a 12-mile (20-kilometer) zone around the nuclear plant. But large sections of land in the area remain off-limits. Many residents aren't expected to be able to return to their homes for years.


Kanno accused the report's authors of exaggerating the cancer risk and stoking fear among residents.


"I'm enraged," he said.


___


Mari Yamaguchi in Tokyo and AP Science Writer Malcolm Ritter in New York contributed to this report.


__


Online:


WHO report: http://bit.ly/YDCXcb


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Stock index futures signal mixed start to March

LONDON (Reuters) - Stock index futures pointed to a mixed open on Wall Street on Friday, with futures for the S&P 500 up 0.3 percent, while Dow Jones and Nasdaq 100 futures were broadly flat at 0956 GMT.


Overnight equity market performance has been mixed, with Tokyo shares edging higher <.n225>, while European bourses were hit by economic growth concerns <.fteu3>.


China's factory growth cooled to multi-month lows in February as domestic demand dipped, weighing on firms already hit by slack foreign sales and underlining the patchiness of the country's economic recovery.


Euro zone manufacturing activity appeared no closer to recovery last month, when a dire performance in France offset a return to growth in Germany, PMI data showed. British manufacturing, meanwhile, shrank unexpectedly.


Absent a highly unlikely last-ditch deal, the $85 billion in cuts across federal government agencies start on Friday after the White House and Republicans failed to reach a deal. The measures are expected to shave at least 0.5 percent off U.S. economic growth.


Groupon Inc fired Andrew Mason as chief executive officer on Thursday, sending its shares up as much as 8 percent in after-hours trade, ousting a co-founder who failed to stop a gradual erosion of its main daily deals business.


Boeing Co will cut hundreds of jobs at a South Carolina plant that makes 787 Dreamliners over the course of this year, but the move has nothing to do with the recent grounding of the troubled jetliner, the Wall Street Journal reported on Thursday.


U.S. government-run mortgage finance provider Freddie Mac earned $11.0 billion last year, the first annual increase in its net income since 2006, the year the nation's housing bubble peaked.


Bank of America Corp BAC.N said in a securities filing on Thursday that the New York State Attorney General was investigating the bank over its purchase, securitization and underwriting of home loans.


Gap Inc's fourth-quarter profit beat estimates, helped by higher comparable store sales in North America and the apparel retailer raised its dividend for this year by 20 percent to 60 cents.


Salesforce.com Inc reported better-than-expected quarterly sales of $835 million on Thursday, as its cloud-based services continued to sell well despite an uncertain macroeconomic picture. Its shares gained 4.9 percent after hours to $177.50.


Paulson & Co, the largest shareholder of MetroPCS Communications Inc , said it will vote against the wireless service provider's proposed merger with T-Mobile USA, a unit of Deutsche Telekom AG , unless the companies sweeten the deal.


Best Buy Co ended talks with founder Richard Schulze over a deal in which he and a group of buyout firms were proposing to take a minority stake in the firm in exchange for three seats on the board, the Wall Street Journal reports, citing people familiar with the matter.


Friday's bumper data calendar features PCE inflation data for January alongside the Thomson Reuters/University of Michigan sentiment index and the Institute for Supply Management's manufacturing index for February.


The Dow Jones industrial average <.dji> fell 20.88 points, or 0.15 percent, to 14,054.49 on Thursday. The Standard & Poor's 500 Index <.spx> lost 1.31 points, or 0.09 percent, to 1,514.68. The Nasdaq Composite Index <.ixic> fell 2.07 points, or 0.07 percent, to end at 3,160.19.


(Reporting by Francesco Canepa and Toni Vorobyova; Editing by Catherine Evans)



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Western governments to discuss military assistance to Syrian rebels: source


ROME (Reuters) - Western and Arab officials will meet representatives of the Syrian opposition in Istanbul next Monday to discuss military and humanitarian support for rebels fighting President Bashar al-Assad, a European diplomatic source said on Thursday.


"The meeting aims to work directly with opposition structures to increase the level of support," the source said, adding that both civilian and military representatives of the Syrian opposition would attend.


The source spoke on the margins of a meeting in Rome between the Syrian National Coalition - the main civilian opposition group - and Western and Arab nations.


In a policy shift, the United States has decided to provide medical supplies and food to Syrian fighters, but will still oppose giving the rebels weapons, a source familiar with the matter said overnight.


(Reporting by Khaled Oweis, Editing By Barry Moody)



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ET at The Sunset Sessions: What do Fun The Black Keys and Jason Mraz Have in Common

When I'm driving home from work listening to the radio I sometimes wonder, How do these radio programmers know what new music is out there? I hear the constant streaming of Top 40 hits, but where are the underground singer-songwriters? Where can radio and music lovers find the new IT group or artist that is going to blow up? Well I found the answer and I have three words for you... the Sunset Sessions.

PICS: New Music Tuesday!

For over 16 years, the sessions have opened their doors to new and upcoming artists, and you won't believe the list of alumni: Grammy winners Jason Mraz, Colbie Caillat, The Zac Brown Band, The Black Keys, and Fun., just to name a few, and did I mention they are all Grammy winners?

Michele Clark, who founded the Sunset Sessions, wanted to create an event that would bring together music supervisors, radio programmers, music managers, all in one place to discover artists and bands no one else is playing.

This past weekend I got to spend some time in San Francisco with some of music's most talked about new artists and groups including the much buzzed about, AlphRev and Saints of Valory. When I arrived at the Grand Hyatt Hotel right in the center of downtown you could feel the energy of the musicians as you stepped into the many rooms and stages to watch the various artists. Though they were all music industry professionals there on business, at the end of the day they are all music lovers in search of new music.

The Parlotones, the multi-platinum selling Johannesburg-bred quartet, who has shared the stage with bands like Coldplay, say that the event has "a cool vibe, everyone's music lovers and meeting each other so it's just a cool vibe." Kansas born rock band, Gooding, who were at the sessions for the first time, said "one of the things that makes it very special is the quality of not only just talent, but the people ... there's just a lot of passion here."

The opportunity is very different than other music industry events as rock and roll songstress, Anna Rose, says "it's rare, you don't get to sit in front of people like this and play ... especially for an independent musician like myself." Country spitfire Emily Bell says that the music professionals "really accept all these up and coming artists with open arms."

The Sunset Sessions have also gathered artists all over the world to come and showcase their music including Sweden's Anna Bergendahl, who performed for the first time in the US during the sessions, Keith Harkin from Ireland, Chris Assaad from Canada, and they even went to the island of Hawaii to bring singer songwriter Anuhea to join the fun; throughout her career she has jammed with the likes of Bruno Mars and Ziggy Marley.

I wasn't sure what to expect but after a full weekend of new music, I was refreshed and cannot wait to see where this year takes all of these new and amazing artists.

To see what other up and coming artists like Faulkner, Savannah Philyaw, and Fernando Perdomo, had to say about the Sunset Sessions and their performances watch the video above and follow @sunsetsessions on Twitter or go to sunsetsessions.org for more details on the next Sunset Sessions in Carlsbad, California.

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Medicare paid $5.1B for poor nursing home care


SAN FRANCISCO (AP) — Medicare paid billions in taxpayer dollars to nursing homes nationwide that were not meeting basic requirements to look after their residents, government investigators have found.


The report, released Thursday by the Department of Health and Human Services' inspector general, said Medicare paid about $5.1 billion for patients to stay in skilled nursing facilities that failed to meet federal quality of care rules in 2009, in some cases resulting in dangerous and neglectful conditions.


One out of every three times patients wound up in nursing homes that year, they landed in facilities that failed to follow basic care requirements laid out by the federal agency that administers Medicare, investigators estimated.


By law, nursing homes need to write up care plans specially tailored for each resident, so doctors, nurses, therapists and all other caregivers are on the same page about how to help residents reach the highest possible levels of physical, mental and psychological well-being.


Not only are residents often going without the crucial help they need, but the government could be spending taxpayer money on facilities that could endanger people's health, the report concluded. The findings come as concerns about health care quality and cost are garnering heightened attention as the Obama administration implements the nation's sweeping health care overhaul.


"These findings raise concerns about what Medicare is paying for," the report said.


Investigators estimate that in one out of five stays, patients' health problems weren't addressed in the care plans, falling far short of government directives. For example, one home made no plans to monitor a patient's use of two anti-psychotic drugs and one depression medication, even though the drugs could have serious side effects.


In other cases, residents got therapy they didn't need, which the report said was in the nursing homes' financial interest because they would be reimbursed at a higher rate by Medicare.


In one example, a patient kept getting physical and occupational therapy even though the care plan said all the health goals had been met, the report said.


The Office of Inspector General's report was based on medical records from 190 patient visits to nursing homes in 42 states that lasted at least three weeks, which investigators said gave them a statistically valid sample of Medicare beneficiaries' experiences in skilled nursing facilities.


That sample represents about 1.1 million patient visits to nursing homes nationwide in 2009, the most recent year for which data was available, according to the review.


Overall, the review raises questions about whether the system is allowing homes to get paid for poor quality services that may be harming residents, investigators said, and recommended that the Centers for Medicare & Medicaid Services tie payments to homes' abilities to meet basic care requirements. The report also recommended that the agency strengthen its regulations and ramp up its oversight. The review did not name individual homes, nor did it estimate the number of patients who had been mistreated, but instead looked at the overall number of stays in which problems arose.


In response, the agency agreed that it should consider tying Medicare reimbursements to homes' provision of good care. CMS also said in written comments that it is reviewing its own regulations to improve enforcement at the homes.


"Medicare has made significant changes to the way we pay providers thanks to the health care law, to reward better quality care," Medicare spokesman Brian Cook said in a statement to AP. "We are taking steps to make sure these facilities have the resources to improve the quality of their care, and make sure Medicare is paying for the quality of care that beneficiaries are entitled to."


CMS hires state-level agencies to survey the homes and make sure they are complying with federal law, and can require correction plans, deny payment or end a contract with a home if major deficiencies come to light. The agency also said it would follow up on potential enforcement at the homes featured in the report.


Greg Crist, a Washington-based spokeswoman for the American Health Care Association, which represents the largest share of skilled nursing facilities nationwide, said overall nursing home operators are well regulated and follow federal guidelines but added that he could not fully comment on the report's conclusions without having had the chance to read it.


"Our members begin every treatment with the individual's personal health needs at the forefront. This is a hands-on process, involving doctors and even family members in an effort to enhance the health outcome of the patient," Crist said.


Virginia Fichera, who has relatives in two nursing homes in New York, said she would welcome a greater push for accountability at skilled nursing facilities.


"Once you're in a nursing home, if things don't go right, you're really a prisoner," said Fichera, a retired professor in Sterling, NY. "As a concerned relative, you just want to know the care is good, and if there are problems, why they are happening and when they'll be fixed."


Once residents are ready to go back home or transfer to another facility, federal law also requires that the homes write special plans to make sure patients are safely discharged.


Investigators found the homes didn't always do what was needed to ensure a smooth transition.


In nearly one-third of cases, facilities also did not provide enough information when the patient moved to another setting, the report found.


___


On the Web:


The OIG report: http://1.usa.gov/VaztQm


The Medicare nursing home database: http://www.medicare.gov/NursingHomeCompare/search.aspx?bhcp=1&AspxAutoDetectCookieSupport=1


___


Follow Garance Burke on Twitter at —http://twitter.com/garanceburke.


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Stock index futures point to slightly higher open

LONDON (Reuters) - Stock index futures pointed to a slightly higher open on Wall Street on Thursday.


Futures for the S&P 500 and the Dow Jones rose 0.2 percent, while contracts on the Nasdaq 100 were up 0.1 percent at 0852 GMT.


European shares also rose as investors took heart from fresh signs that central banks would continue steps to support the world's economy.


Revised U.S. GDP data at 1330 GMT is expected to show the U.S. economy grew by 0.5 percent in the fourth quarter, rather than a 0.1 percent contraction as initially estimated.


Weekly new jobless claims figures, due at the same time, are seen slowing to 360,000 from 362,000 in the previous seven days.


February's Chicago PMI, due out at 1445 GMT, is expected to come in at 54.3, from 55.6 last month.


Liberty Media Corp , which holds a large stake in Barnes & Noble, said on Wednesday it had the power to block a sale of Barnes & Nobles' retail stores and it is waiting to see whether the bookseller's chairman Leonard Riggio will make an offer.


J.C. Penney Co Inc on Wednesday reported its sharpest sales drop since announcing a grand transformation plan 13 months ago, sending shares in the department store operator's shares down 14.5 percent in after hours trading.


Groupon Inc lost a quarter of its market value in after hours trading on Wednesday after the company revealed it began to take a smaller cut of revenue on daily deals during the holidays, sacrificing revenue and profits to attract and keep merchants.


Business software provider Salesforce.com and clothes retailer Gap are due to report results after the market close.


U.S. authorities investigating possible insider trading in ketchup maker H.J. Heinz Co are studying a derivatives bet that was routed through London, the New York Times reported, citing two people briefed on the matter.


Bond insurer MBIA Inc said there was a significant risk that its structured finance insurance unit would be put into liquidation or rehabilitation by its New York regulator if it was unable to settle its claims with Bank of America .


Generic drugmaker Mylan Inc said it will buy a unit of India's Strides Arcolab Ltd for $1.6 billion to expand its presence in the fast-growing injectable drugs market.


The U.S. Justice Department said on Wednesday it has won a $1 billion tax shelter case against Dow Chemical Co that involved a Swiss partnership, Wall Street financial giant Goldman Sachs and international law firm King & Spalding.


The Dow Jones industrial average <.dji> was up 176.32 points, or 1.27 percent, at 14,076.45 on Wednesday. The Standard & Poor's 500 Index <.spx> was up 19.07 points, or 1.27 percent, at 1,516.01. The Nasdaq Composite Index <.ixic> was up 32.61 points, or 1.04 percent, at 3,162.26.


(Reporting by Francesco Canepa; Editing by Alison Williams)



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World powers and Iran set new talks in nuclear dispute


ALMATY (Reuters) - Six world powers ended two days of talks with Iran on its nuclear program without a breakthrough on Wednesday, but agreed to meet in Istanbul next month and resume negotiations in Kazakhstan on April 5.


The six powers - France, Germany, the United States, China Russia and Britain - offered at the talks to lift some sanctions if Iran scaled back nuclear activity that the West fears could be used to build a bomb.


Tehran, which denies seeking nuclear weapons, did not agree to do so and the sides did not appear any closer to an agreement to resolve a decade-old dispute that could lead to another war in the Middle East if diplomacy fails.


But Iran said the talks were a positive step in which the six powers tried to "get closer to our viewpoint", and Western diplomats had set their sights low, making clear that an agreement to meet again soon would be deemed a success.


In particular, they are aware that the closeness of Iran's presidential election in June is raising political tensions in Tehran and makes significant concessions unlikely.


"I hope the Iranian side is looking positively on the proposal we put forward," said European Union foreign policy chief Catherine Ashton, who led the talks on behalf of the six powers. "We have to see what happens next."


Israel, assumed to be the only country in the Middle East with nuclear weapons, has hinted strongly that it could attack Iran's nuclear sites if diplomacy and sanctions do not stop its enrichment of uranium to near weapons-grade.


MORE MEETINGS SCHEDULED


One diplomat in Almaty said the Iranians appeared to be suggesting at the talks that they were opening new avenues, but that it was not clear if this was really the case.


Both sides said experts would meet for talks in the Turkish city of Istanbul on March 18 and that political negotiators would return to Almaty on April 5-6.


The meeting in the Kazakh city was the first between the world powers and Iran in eight months.


Russian negotiator Sergei Ryabkov confirmed that the six powers had offered to ease sanctions on Iran if it stops enriching uranium to 20 percent fissile purity - a short technical step from weapons grade - at an underground site where it carries out its most controversial uranium enrichment work.


Western officials said the offer of sanctions relief included a resumption of trade in gold and precious metals and lifting an embargo on imports of petrochemical products if Iran responded. But a U.S. official said the world powers had not offered to suspend oil or financial sanctions.


The sanctions are hurting Iran's economy and its chief nuclear negotiator, Saeed Jalili, suggested Iran could discuss its production of nuclear fuel, although he appeared to rule out closing the underground enrichment plant at Fordow.


In comments in Persian translated into English, Jalili told a news conference Fordow was under the supervision of the U.N. nuclear watchdog and there was no justification for closing it.


"RIGHT TO ENRICHMENT"


Asked about the production of 20-percent enriched fuel, he reiterated Iran's position that it needed this for a research reactor and had a right to produce it.


Iran says its enrichment program is aimed solely at producing nuclear energy so that it can export more oil, and that Israel's assumed nuclear arsenal is the main threat to peace in the region.


But Jalili did indicate that Iran might be prepared to discuss the issue, saying: "This can be discussed in the negotiations ... in view of confidence building."


Iran has also previously suggested that 20-percent enrichment was up for negotiation if it received the fuel from abroad instead. It also wants sanctions lifted.


"While an agreement to meet again may not impress skeptics of diplomacy, an important development did occur," said Trita Parsi, an expert on Iran. "The parties began searching for a solution by offering positive measures in order to secure concessions from the other side.


"In past meetings, the approach centered on coercion - the main motivator for concessions was the threat of new sanctions and other escalatory steps."


Ali Vaez of the International Crisis group said the powers had broken a taboo by discussing sanctions relief.


Another expert, Dina Esfandiary of the International Institute for Strategic Studies, said: "I note that the mood is more optimistic and that's great, but a deal still hasn't been reached and in my view its unlikely to be reached before the Iranian elections have come and gone."


(Additional reporting by Yeganeh Torbati in Almaty, Zahra Hosseinian in Zurich, Gabriela Baczynska in Moscow, Dan Williams in Jerusalem and Marcus George in Dubai; Writing by Timothy Heritage and Fredrik Dahl; Editing by Kevin Liffey)



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Tina Fey and Amy Poehler Will Never Host the Oscars Together

To the dismay of William Shatner and fans around the world, Tina Fey recently revealed that she has no intention of ever emceeing the Academy Awards ceremony with or without her BFF, and Golden Globes co-host, Amy Poehler.

Pics: The 2013 Oscars!

When asked if she'd ever consider the gig, Fey told The Huffington Post that she wouldn't dare sign up for the task because the Oscars are far too much work.

"I just feel like that gig is so hard," she said, adding that her gender would make hosting duties extremely taxing.

Related: Stars React to Tina & Amy's Golden Globes Hosting Gig

Mused Fey, "The amount of months that would be spent trying on dresses alone ... no way."

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Advanced breast cancer edges up in younger women


CHICAGO (AP) — Advanced breast cancer has increased slightly among young women, a 34-year analysis suggests. The disease is still uncommon among women younger than 40, and the small change has experts scratching their heads about possible reasons.


The results are potentially worrisome because young women's tumors tend to be more aggressive than older women's, and they're much less likely to get routine screening for the disease.


Still, that doesn't explain why there'd be an increase in advanced cases and the researchers and other experts say more work is needed to find answers.


It's likely that the increase has more than one cause, said Dr. Rebecca Johnson, the study's lead author and medical director of a teen and young adult cancer program at Seattle Children's Hospital.


"The change might be due to some sort of modifiable risk factor, like a lifestyle change" or exposure to some sort of cancer-linked substance, she said.


Johnson said the results translate to about 250 advanced cases diagnosed in women younger than 40 in the mid-1970s versus more than 800 in 2009. During those years, the number of women nationwide in that age range went from about 22 million to closer to 30 million — an increase that explains part of the study trend "but definitely not all of it," Johnson said.


Other experts said women delaying pregnancy might be a factor, partly because getting pregnant at an older age might cause an already growing tumor to spread more quickly in response to pregnancy hormones.


Obesity and having at least a drink or two daily have both been linked with breast cancer but research is inconclusive on other possible risk factors, including tobacco and chemicals in the environment. Whether any of these explains the slight increase in advanced disease in young women is unknown.


There was no increase in cancer at other stages in young women. There also was no increase in advanced disease among women older than 40.


Overall U.S. breast cancer rates have mostly fallen in more recent years, although there are signs they may have plateaued.


Some 17 years ago, Johnson was diagnosed with early-stage breast cancer at age 27, and that influenced her career choice to focus on the disease in younger women.


"Young women and their doctors need to understand that it can happen in young women," and get checked if symptoms appear, said Johnson, now 44. "People shouldn't just watch and wait."


The authors reviewed a U.S. government database of cancer cases from 1976 to 2009. They found that among women aged 25 to 39, breast cancer that has spread to distant parts of the body — advanced disease — increased from between 1 and 2 cases per 100,000 women to about 3 cases per 100,000 during that time span.


The study was published Tuesday in the Journal of the American Medical Association.


About one in 8 women will develop breast cancer in their lifetime, but only 1 in 173 will develop it by age 40. Risks increase with age and certain gene variations can raise the odds.


Routine screening with mammograms is recommended for older women but not those younger than 40.


Dr. Len Lichtenfeld, the American Cancer Society's deputy chief medical officer, said the results support anecdotal reports but that there's no reason to start screening all younger women since breast cancer is still so uncommon for them.


He said the study "is solid and interesting and certainly does raise questions as to why this is being observed." One of the most likely reasons is probably related to changes in childbearing practices, he said, adding that the trend "is clearly something to be followed."


Dr. Ann Partridge, chair of the federal Centers for Disease Control and Prevention's advisory committee on breast cancer in young women, agreed but said it's also possible that doctors look harder for advanced disease in younger women than in older patients. More research is needed to make sure the phenomenon is real, said Partridge, director of a program for young women with breast cancer at the Harvard-affiliated Dana-Farber Cancer Institute.


The study shouldn't cause alarm, she said. Still, Partridge said young women should be familiar with their breasts and see the doctor if they notice any lumps or other changes.


Software engineer Stephanie Carson discovered a large breast tumor that had already spread to her lungs; that diagnosis in 2003 was a huge shock.


"I was so clueless," she said. "I was just 29 and that was the last thing on my mind."


Carson, who lives near St. Louis, had a mastectomy, chemotherapy, radiation and other treatments and she frequently has to try new drugs to keep the cancer at bay.


Because most breast cancer is diagnosed in early stages, there's a misconception that women are treated, and then get on with their lives, Carson said. She and her husband had to abandon hopes of having children, and she's on medical leave from her job.


"It changed the complete course of my life," she said. "But it's still a good life."


____


Online:


JAMA: http://jama.ama-assn.org


CDC: http://www.cdc.gov/cancer/breast/index.htm


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Stock index futures signal mixed open

LONDON (Reuters) - Stock index futures pointed to a mixed Wall Street open on Wednesday, with futures for the S&P 500 and Nasdaq 100 indexes slipping 0.1 percent, while futures for the Dow Jones rose 0.1 percent by 0933 GMT.


U.S. durables goods and homes data due out at 1330 and 1500 GMT respectively should provide further clues on the health of the world's largest economy.


The Pentagon program chief for the F-35 warplane slammed its commercial partners Lockheed Martin and Pratt & Whitney on Wednesday, accusing them of trying to "squeeze every nickel" out of the U.S. government and failing to see the long-term benefits of the project.


Pratt & Whitney is 99 percent sure the fan blade problem that grounded the Pentagon's 51 new F-35 fighter jets was not caused by high-cycle fatigue, which could force a costly design change, according to two sources familiar with an investigation by the enginemaker.


Airbus parent EADS predicted higher profit this year on the heels of stronger than expected 2012 earnings and a clampdown on costs, with the development of its A350 jet remaining the biggest wild card in its bid to match rival Boeing .


Partner Communications , Israel's second-largest mobile phone operator, reported weaker-than-expected quarterly profit and said it could have weak earnings throughout 2013 due to fierce competition that has slashed calling rates.


The pan-European FTSEurofirst 300 index <.fteu3> was up 0.1 percent at 1,151.69 points by 1010 GMT on Wednesday while the euro zone's Euro STOXX 50 index <.stoxx50e> also advanced 0.1 percent, although concerns over Italy's political stalemate were likely to cap gains.


The Dow Jones industrial average <.dji> gained 115.96 points, or 0.84 percent, to 13,900.13 at the close on Tuesday. The Standard & Poor's 500 Index <.spx> rose 9.09 points, or 0.61 percent, to 1,496.94. The Nasdaq Composite Index <.ixic> advanced 13.40 points, or 0.43 percent, to close at 3,129.65.


(Reporting by Sudip Kar-Gupta; Editing by Susan Fenton)



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